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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
17
hits in this display
Target
Substance-K receptor
(Homo sapiens (Human))
Creighton University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
Ki: 0.710nM
Assay Description:
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
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Target
Substance-K receptor
(Homo sapiens (Human))
Creighton University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
Ki: 1.20nM
Assay Description:
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
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Target
Substance-P receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
Ki: 630nM
Assay Description:
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
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Target
Substance-K receptor
(GUINEA PIG)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
Ki: 3.70E+3nM
Assay Description:
Evaluated for the binding affinity against NK2 receptor
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Target
Substance-K receptor
(HAMSTER)
Marion Merrell Dow Research Institute
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
IC50: 1nM
Assay Description:
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
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Target
Substance-K receptor
(Homo sapiens (Human))
Creighton University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
IC50: 1.70nM
Assay Description:
Inhibitory activity against human Tachykinin receptor 2
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Target
Substance-P receptor
(GUINEA PIG)
TBA
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
IC50: 3.5nM
Assay Description:
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
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Target
Substance-K receptor
(Homo sapiens (Human))
Creighton University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
IC50: 7.70nM
Assay Description:
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
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Target
Substance-P receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
IC50: 31nM
Assay Description:
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
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Target
Substance-P receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
IC50: 32nM
Assay Description:
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]-BH-SP as radioligand
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Target
Neuromedin-K receptor
(Homo sapiens (Human))
Merck Sharp Laboratory
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
IC50: 45nM
Assay Description:
Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cells
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Target
Neuromedin-K receptor
(Homo sapiens (Human))
Merck Sharp Laboratory
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
EC50: 53nM
Assay Description:
Compound was evaluated in vitro for the inhibition of dog liver squalene epoxidase in HepG2 cells
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Target
Substance-K receptor
(Rattus norvegicus (Rat))
Umr Uds/Cnrs 7200
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
EC50: 64.8nM
Assay Description:
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
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Target
Substance-K receptor
(Rattus norvegicus (Rat))
Umr Uds/Cnrs 7200
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
EC50: 0.550nM
Assay Description:
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
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Target
Substance-P receptor
(GUINEA PIG)
TBA
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
EC50: 14nM
Assay Description:
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
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Target
Substance-K receptor
(Rattus norvegicus (Rat))
Umr Uds/Cnrs 7200
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
EC50: 1.70nM
Assay Description:
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
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Target
Neuromedin-K receptor
(Rattus norvegicus)
Glaxo Group Research
Curated by
ChEMBL
Ligand
BDBM50001447
(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
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Affinity Data
EC50: 563nM
Assay Description:
In vitro agonistic activity against tachykinin receptor 3 of everted rat protal vein.
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