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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Industrial Research

LigandPNGBDBM22110(Azetidine based compound, 43 | [1-({4-amino-5H-pyr...)
Affinity DataKi:  0.840nM ΔG°:  -51.3kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research

LigandPNGBDBM22110(Azetidine based compound, 43 | [1-({4-amino-5H-pyr...)
Affinity DataKi:  140nM ΔG°:  -38.7kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteine nucleosidase(Streptococcus pneumoniae)
Industrial Research

LigandPNGBDBM22110(Azetidine based compound, 43 | [1-({4-amino-5H-pyr...)
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed