Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50:  10nMAssay Description:In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50:  10.5nMAssay Description:Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Kir1.1 expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50:  1.80E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed