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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
ATP-sensitive inward rectifier potassium channel 1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50121345
(CHEMBL3622104 | US9751881, Example 1)
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Affinity Data
IC50: 10nM
Assay Description:
In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinity
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
ATP-sensitive inward rectifier potassium channel 1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50121345
(CHEMBL3622104 | US9751881, Example 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 10.5nM
Assay Description:
Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
ATP-sensitive inward rectifier potassium channel 1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50121345
(CHEMBL3622104 | US9751881, Example 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibition of human Kir1.1 expressed in HEK293 cells by thallium flux assay
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50121345
(CHEMBL3622104 | US9751881, Example 1)
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Copy InChI
Affinity Data
IC50: 1.80E+3nM
Assay Description:
Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI