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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50152917
(CHEMBL361376 | N-Hydroxy-2-{3-[4-(2-methyl-quinoli...)
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Affinity Data
Ki: >2.10E+3nM
Assay Description:
Inhibition of Matrix metalloprotease-9 (MMP-9)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50152917
(CHEMBL361376 | N-Hydroxy-2-{3-[4-(2-methyl-quinoli...)
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Affinity Data
Ki: >3.30E+3nM
Assay Description:
inhibition of Matrix metalloprotease-2 (MMP-2)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50152917
(CHEMBL361376 | N-Hydroxy-2-{3-[4-(2-methyl-quinoli...)
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Affinity Data
Ki: >4.90E+3nM
Assay Description:
Inhibition of Matrix metalloprotease-1 (MMP-1)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Collagenase 3
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50152917
(CHEMBL361376 | N-Hydroxy-2-{3-[4-(2-methyl-quinoli...)
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Affinity Data
Ki: >5.00E+3nM
Assay Description:
Inhibition of Matrix metalloprotease-13 (MMP-13)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50152917
(CHEMBL361376 | N-Hydroxy-2-{3-[4-(2-methyl-quinoli...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of porcine Tumor necrosis factor- alpha converting enzyme (TACE, ADAM17)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50152917
(CHEMBL361376 | N-Hydroxy-2-{3-[4-(2-methyl-quinoli...)
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Copy InChI
Affinity Data
IC50: 595nM
Assay Description:
Effect on TNF-Alpha release in LPS-stimulated human whole blood assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI