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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50332963
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
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Affinity Data
IC50: 2nM
Assay Description:
Partial displacement of [3H]LY354740 from recombinant rat mGluR2
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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Ligand Info
CHEMBL
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Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50332963
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
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Copy InChI
Affinity Data
IC50: 3nM
Assay Description:
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50332963
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
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Copy InChI
Affinity Data
IC50: 14nM
Assay Description:
Antagonist activity at human mGluR2 receptor expressed in CHO cells assessed as inhibition of GIRK current
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 3
(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by
ChEMBL
Ligand
BDBM50332963
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
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Affinity Data
IC50: 270nM
Assay Description:
Negative allosteric modulation of mGlu3 receptor (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 3
(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by
ChEMBL
Ligand
BDBM50332963
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 270nM
Assay Description:
Negative allosteric modulation of mGlu3 by cell-based assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50332963
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 296nM
Assay Description:
Negative allosteric modulation of mGlu2 by cell-based assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50332963
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 296nM
Assay Description:
Negative allosteric modulation of mGlu2 receptor (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM50332963
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
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Affinity Data
IC50: 4.80E+3nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
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