Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis

US Patent

LigandBDBM186047(US9163011, 1)Copy SMILESCopy InChI

Affinity DataIC50:  7nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetBeta-secretase 1(Homo sapiens (Human))
Novartis

US Patent

LigandBDBM186047(US9163011, 1)Copy SMILESCopy InChI

Affinity DataIC50:  12nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 1 nM concentrations is incubated wi...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetBeta-secretase 2(Homo sapiens (Human))
Novartis

US Patent

LigandBDBM186047(US9163011, 1)Copy SMILESCopy InChI

Affinity DataIC50:  66nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 1 nM concentrations is incubated wi...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI