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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
2
hits in this display
Target
RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM88093
(US9694016, 1126)
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Affinity Data
IC50: 0.5nM
pH: 7.5 T: 2°C
Assay Description:
Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Serine/threonine-protein kinase B-raf [V600E]
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM88093
(US9694016, 1126)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.85nM
pH: 7.5 T: 2°C
Assay Description:
Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI