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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
16
hits in this display
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
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Affinity Data
Ki: 17nM
Assay Description:
Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17nM
Assay Description:
Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 588nM
Assay Description:
Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 588nM
Assay Description:
Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 589nM
Assay Description:
Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3nM
Assay Description:
Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human))
Glaxosmithkline
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
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Affinity Data
IC50: 3nM
pH: 7.4 T: 2°C
Assay Description:
The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.20nM
Assay Description:
Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 20nM
Assay Description:
Inhibition of RIP2K in MDP-stimulated HEK-293 cells over-expressing NOD2 assessed as IL8 secretion
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 177nM
Assay Description:
Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 177nM
Assay Description:
Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 186nM
Assay Description:
Inhibition of VEGFR2(unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of p38alpha (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 775nM
Assay Description:
Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 775nM
Assay Description:
Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM25198
(3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of RIP2K in Pam2CSK4-stimulated HEK-293 cells over-expressing TLR2 assessed as IL8 secretion
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI