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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
14
hits in this display
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 14nM
Assay Description:
Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
The enzymatic assay of LSD-1 activity is based on Tnne Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
T: 2°C
Assay Description:
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
T: 2°C
Assay Description:
This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Fount Therapeutics
Curated by
ChEMBL
Ligand
BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
To analyze LSD1 inhibitor efficacy in cells, a CD11b flow cytometry assay was performed. LSD1 inhibition induces CD11b expression in THP-1 (AML) cell...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI