Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 56 hits in this display
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
IC50: 170nMAssay Description:p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
IC50: 334nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
IC50: 334nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
IC50: 334nMAssay Description:c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashio...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
IC50: 334nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
IC50: 334nMAssay Description:c-Src and SyK: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both don...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
IC50: 3.74E+3nMAssay Description:p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashi...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
IC50: >1.70E+4nMAssay Description:GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 14nMAssay Description:c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashio...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 2.00E+4nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 14nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 20nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 43nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 8nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 10nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 14nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 2.00E+4nMAssay Description:The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 1.20E+3nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 10nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 2.00E+4nMAssay Description:GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 43nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 20nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 20nMAssay Description:p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 43nMAssay Description:p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashi...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 2.00E+4nMAssay Description:The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 14nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 10nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 1.20E+3nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 20nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 10nMAssay Description:c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashio...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 8nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 1.20E+3nMAssay Description:The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m...More data for this Ligand-Target Pair
BDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Kd: 43nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
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