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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Heptares Therapeutics
US Patent
Ligand
BDBM50113474
(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
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Affinity Data
Ki: 2.45nM
Assay Description:
After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Heptares Therapeutics
US Patent
Ligand
BDBM50113474
(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.45nM
Assay Description:
Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Heptares Therapeutics
US Patent
Ligand
BDBM50113474
(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.45nM
Assay Description:
After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Heptares Therapeutics
US Patent
Ligand
BDBM50113474
(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.5nM
Assay Description:
Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Heptares Therapeutics
US Patent
Ligand
BDBM50113474
(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI