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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataKi:  2.45nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataKi:  2.45nMAssay Description:Membrane PreparationcDNA encoding the human mGlu5 receptor was transfected into HEK293 cells using the transfection reagent Genejuice (Novagen). Fort...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataKi:  2.45nMAssay Description:After thawing, membrane homogenates were re-suspended in the binding buffer (50 mM HEPES pH 7.5, 150 mM NaCl) to a final assay concentration of 2.5 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

US Patent
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataIC50:  5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed