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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153688(US10507215, Compound 5 | US9000015, 5)
Affinity DataIC50:  166nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM153688(US10507215, Compound 5 | US9000015, 5)
Affinity DataIC50:  166nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Amygdala Neurosciences

US Patent
LigandPNGBDBM153688(US10507215, Compound 5 | US9000015, 5)
Affinity DataIC50: >1.30E+5nMAssay Description:MAO assays included lumnuogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Amygdala Neurosciences

US Patent
LigandPNGBDBM153688(US10507215, Compound 5 | US9000015, 5)
Affinity DataIC50: >1.30E+5nMAssay Description:MAO assays included lumnuogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Amygdala Neurosciences

US Patent
LigandPNGBDBM153688(US10507215, Compound 5 | US9000015, 5)
Affinity DataIC50: >1.30E+5nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with eserase. Standard MAO reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Amygdala Neurosciences

US Patent
LigandPNGBDBM153688(US10507215, Compound 5 | US9000015, 5)
Affinity DataIC50: >1.30E+5nMpH: 7.5Assay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with eserase. Standard MAO reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent