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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
29
hits in this display
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19nM
Assay Description:
Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19nM
Assay Description:
Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.20nM
Assay Description:
Inhibition of human ERG by fluorescently labeled tracer binding method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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UniProtKB/SwissProt
UniProtKB/TrEMBL
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.70nM
Assay Description:
K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
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UniProtKB/SwissProt
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.76nM
Assay Description:
Inhibition of human ERG in MCF7 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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UniProtKB/SwissProt
UniProtKB/TrEMBL
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.80nM
Assay Description:
Inhibition of fluorescently labeled tracer binding to human ERG by competitive binding assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 10nM
Assay Description:
Inhibition of red tracer binding to human ERG expressed in membranes preincubated for 10 to 15 mins followed by tracer addition measured after 3 hrs ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
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antibodypedia
GoogleScholar
Ligand Info
Purchase
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 12.0nM
Assay Description:
Inhibition of human ERG
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 18.1nM
Assay Description:
Inhibition of human ERG channel
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
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antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 19.9nM
Assay Description:
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 19.9nM
Assay Description:
Inhibitory concentration against potassium channel HERG
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 20nM
Assay Description:
Inhibitory concentration against IKr potassium channel
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
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GoogleScholar
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CHEMBL
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In Depth
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Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 20nM
Assay Description:
Inhibition of human Potassium channel HERG expressed in mammalian cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 20nM
Assay Description:
Inhibition of wild-type human ERG expressed in HEK293 cells by whole cell patch clamp method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 21nM
Assay Description:
Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 22.9nM
Assay Description:
Inhibition of human ERG channel in HEK293 cells by voltage-clamp method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 24nM
Assay Description:
Inhibition of human ERG expressed in CHOK1 cells assessed as inhibition of tail current after 5 mins by automated whole-cell patch clamp assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 24nM
Assay Description:
Inhibition of human ERG incubated for 3 hrs by competitive fluorescence tracer binding based assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 24nM
Assay Description:
Inhibition of human ERG tail current by patch clamp method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 27nM
Assay Description:
Inhibition of human ERG expressed in HEK293 cells by patch clamp assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 43nM
Assay Description:
Inhibition of hERG measured by fluorescence polarization assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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In Depth
Details
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 70nM
Assay Description:
Inhibition of human ERG expressed in cell membranes after 4 hrs by fluorescence polarization assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 89nM
Assay Description:
Inhibition of human ERG expressed in CHO cells assessed as reduction in channel current at holding potential of 0 mV by electrophysiological method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 89nM
Assay Description:
Inhibition of human ERG expressed in CHO cells with 0 mV holding potential by Ionworks electrophysiology assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
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antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 89nM
Assay Description:
Inhibition of human cloned ERG expressed in CHO cells assessed as inhibition of potassium channel current by automated patch clamp assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
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In Depth
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <300nM
Assay Description:
Inhibition of tracer Red binding to human ERG expressed in membranes after 3 hrs by fluorescence polarization assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
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UniProtKB/SwissProt
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Cavia porcellus)
Jagiellonian University
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.41E+5nM
Assay Description:
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50117930
((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 25nM
Assay Description:
Inhibition of human ERG assessed as reduction of tail current
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
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GoogleScholar
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