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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Tyrosine-protein kinase SYK
(Homo sapiens (Human))
Punjabi University
Curated by
ChEMBL
Ligand
BDBM50249287
(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
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Affinity Data
IC50: 30nM
Assay Description:
Inhibition of spleen tyrosine kinase (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Tyrosine-protein kinase SYK
(Homo sapiens (Human))
Punjabi University
Curated by
ChEMBL
Ligand
BDBM50249287
(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
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Copy InChI
Affinity Data
IC50: 30nM
Assay Description:
Inhibition of recombinant Syk (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase SYK
(Homo sapiens (Human))
Punjabi University
Curated by
ChEMBL
Ligand
BDBM50249287
(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
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Copy InChI
Affinity Data
IC50: 63nM
Assay Description:
Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Aurora kinase B
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50249287
(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
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Affinity Data
IC50: 1.26E+3nM
Assay Description:
Inhibition of human recombinant Flag-6His-Thr-tagged Aurora B assessed as phosphorylation of 5FAM-PKA-tide substrate after 150 mins by fuorescence po...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50249287
(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of human ERG expressed in CHO-K1 cells after 2 hrs by Cy3b-Dofetilide-based fluorescence polarisation assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50249287
(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
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Affinity Data
IC50: 5.01E+3nM
Assay Description:
Inhibition of ZAP70
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50249287
(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
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Affinity Data
IC50: 5.20E+3nM
Assay Description:
Inhibition of human GST-fused ZAP-70 expressed in Sf9 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Venus kinase receptor 2
(Schistosoma mansoni)
Imperial College London
Curated by
ChEMBL
Ligand
BDBM50249287
(2-(2-aminoethylamino)-4-(m-tolylamino)pyrimidine-5...)
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Affinity Data
Kd: 4.50E+3nM
Assay Description:
Binding affinity to Schistosoma mansoni N-terminal His6-tagged full-length VKR2 kinase domain expressed in baculovirus infected Sf9 insect cells in p...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
PubMed
Copy BDB DOI