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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Mitogen-activated protein kinase 9
(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by
ChEMBL
Ligand
BDBM31831
(quinazoline-pyrazolourea hybrid compound, 3e)
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Affinity Data
IC50: 150nM
Assay Description:
Inhibition of JNK2 active form by HTRF assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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Target
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken))
Chemical Genomics Centre Of The Max Planck Society
Ligand
BDBM31831
(quinazoline-pyrazolourea hybrid compound, 3e)
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Affinity Data
IC50: 235nM Kd: 239nM
pH: 7.0 T: 2°C
Assay Description:
IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by
ChEMBL
Ligand
BDBM31831
(quinazoline-pyrazolourea hybrid compound, 3e)
Copy SMILES
Copy InChI
Affinity Data
IC50: 320nM
Assay Description:
Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by
ChEMBL
Ligand
BDBM31831
(quinazoline-pyrazolourea hybrid compound, 3e)
Copy SMILES
Copy InChI
Affinity Data
IC50: 420nM
Assay Description:
Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Mitogen-activated protein kinase 9
(Homo sapiens (Human))
Chemical Genomics Centre Of The Max Planck Society
Curated by
ChEMBL
Ligand
BDBM31831
(quinazoline-pyrazolourea hybrid compound, 3e)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.20E+3nM
Assay Description:
Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Proto-oncogene tyrosine-protein kinase Src [251-533,T338M]
(Gallus gallus (Chicken))
Chemical Genomics Centre Of The Max Planck Society
Ligand
BDBM31831
(quinazoline-pyrazolourea hybrid compound, 3e)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.68E+4nM
pH: 7.0 T: 2°C
Assay Description:
IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI