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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
23
hits in this display
Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 4.10nM
Assay Description:
Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assay
More data for this Ligand-Target Pair
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Target
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human))
Ewha Womans University
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 44nM
Assay Description:
Inhibition of RIPK2 (unknown origin) by radioisotopic assay
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Copy InChI
Affinity Data
IC50: 51nM
Assay Description:
Inhibition of human ALK5 expressed in Sf9 insect cells using casein as substrate in presence of [gamma-33P]ATP
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 56nM
Assay Description:
Inhibition of TGFBR1 (unknown origin)
More data for this Ligand-Target Pair
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: 69nM
Assay Description:
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...
More data for this Ligand-Target Pair
Target Info
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Target
TGF-beta receptor type-1
(Mus musculus)
Ewha Womans University
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: >100nM
Assay Description:
Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assay
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Target Info
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: >100nM
Assay Description:
Inhibition of ALK5 in human HaCaT cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: 119nM
Assay Description:
Inhibition of recombinant GST-tagged human ALK5 expressed in baculovirus infected Sf9 insect cells
More data for this Ligand-Target Pair
Target Info
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: 119nM
Assay Description:
Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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MCE
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PubMed
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 127nM
Assay Description:
Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: 129nM
Assay Description:
Inhibition of recombinant human GST-fused ALK5 expressed in baculovirus infected Sf9 cells assessed as incoporation of [33]Pi after 60 mins in presen...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
antibodypedia
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MCE
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: 129nM
Assay Description:
Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: 170nM
Assay Description:
Inhibition of human TGF-beta-R1 using TMB substrate incubated for 2.5 hrs by microplate reader analysis
More data for this Ligand-Target Pair
Target Info
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Target
Activin receptor type-1B
(Homo sapiens (Human))
Ewha Womans University
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 199nM
Assay Description:
Inhibition of ALK4 (unknown origin) by radioisotopic assay
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Target
Mitogen-activated protein kinase kinase kinase kinase 4
(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 263nM
Assay Description:
Inhibition of recombinant human GST-tagged MAP4K4 expressed in baculovirus expression system using 5-FAM-KRELVEPLTPSGEAPNQALLR-CONH2 substrate preinc...
More data for this Ligand-Target Pair
Target Info
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Target
Mitogen-activated protein kinase kinase kinase kinase 4
(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 280nM
Assay Description:
Inhibition of wild type partial length human MAP4K4 (M1 to R310 residues) expressed in bacterial expression system measured by Kinomescan assay
More data for this Ligand-Target Pair
Target Info
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Target
TGF-beta receptor type-1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
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Affinity Data
IC50: 405nM
Assay Description:
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay
More data for this Ligand-Target Pair
Target Info
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Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Ewha Womans University
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 442nM
Assay Description:
Inhibition of VEGFR2 (unknown origin) by radioisotopic assay
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Target Info
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Yanbian University
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
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Affinity Data
IC50: 487nM
Assay Description:
Inhibition of recombinant human p38alpha expressed in Escherichia coli
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Yanbian University
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
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Affinity Data
IC50: 490nM
Assay Description:
Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Yanbian University
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: 493nM
Assay Description:
Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Yanbian University
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
Copy InChI
Affinity Data
IC50: 493nM
Assay Description:
Inhibition of recombinant human p38alpha expressed in Escherichia coli assessed as incoporation of [33]Pi after 60 mins in presence of [gamma-33P]-AT...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
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DrugBank
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Target
TGF-beta receptor type-2
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM50015640
(GALUNISERTIB | LY-2157299)
Copy SMILES
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Inhibition of wild type His-tagged TGFbetaR2 (unknown origin) after 1 hr by HTRF assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
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GoogleScholar
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