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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50345562
(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
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Affinity Data
Ki: 0.670nM
Assay Description:
Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50345562
(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
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Copy InChI
Affinity Data
IC50: 1.22nM
Assay Description:
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50345562
(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.40nM
Assay Description:
Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI