Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM141510(US8921370, 178 | US9656975, 178)
Affinity DataKi:  370nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM141510(US8921370, 178 | US9656975, 178)
Affinity DataKi:  370nM ΔG°:  -36.7kJ/molepH: 7.4 T: 2°CAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol. Pharmacol., 2003, 64, 731-740] with slight modifications, including that a r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM141510(US8921370, 178 | US9656975, 178)
Affinity DataIC50:  38nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM141510(US8921370, 178 | US9656975, 178)
Affinity DataIC50:  38nMpH: 7.4 T: 2°CAssay Description:The cDNA for rat metabotropic glutamate receptor 5 (rmGluR5) and the cDNA for human metabotropic glutamate receptor 5 (rmGluR5) were generous gifts f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent