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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 2nMMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 2nMMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 2nMMore data for this Ligand-Target Pair

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Ephrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 4nMMore data for this Ligand-Target Pair

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Carbonic anhydrase 2(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 4.10nMAssay Description:Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Ephrin type-B receptor 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 15nMMore data for this Ligand-Target Pair

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Carbonic anhydrase 1(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 29.3nMAssay Description:Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Ephrin type-B receptor 4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 37nMMore data for this Ligand-Target Pair

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Carbonic anhydrase 9(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 41.9nMAssay Description:Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Carbonic anhydrase 15(Mus musculus)
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 79nMAssay Description:Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Carbonic anhydrase 7(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 99nMAssay Description:Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Carbonic anhydrase 14(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 223nMAssay Description:Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Carbonic anhydrase 12(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 302nMAssay Description:Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Carbonic anhydrase 3(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 443nMAssay Description:Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Carbonic anhydrase 4(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 446nMAssay Description:Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Carbonic anhydrase 6(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 461nMAssay Description:Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 2.14E+3nMMore data for this Ligand-Target Pair

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Angiopoietin-1 receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 3.60E+3nMMore data for this Ligand-Target Pair

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PDB NCI pathway Reactome pathway
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 3.95E+3nMMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Lyn(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 4.07E+3nMMore data for this Ligand-Target Pair

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Insulin receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 4.10E+3nMMore data for this Ligand-Target Pair

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Carbonic anhydrase 13(Mus musculus (mouse))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 4.67E+3nMAssay Description:Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Tyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 4.72E+3nMMore data for this Ligand-Target Pair

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Cytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 4.81E+3nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Carbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 5.49E+3nMAssay Description:Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Hepatocyte growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 7.10E+3nMMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 7.22E+3nMMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Fgr(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 7.74E+3nMMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 8.02E+3nMMore data for this Ligand-Target Pair

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BDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 8.24E+3nMMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 8.37E+3nMMore data for this Ligand-Target Pair

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Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 8.54E+3nMMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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Ret proto-oncogene(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 8.68E+3nMMore data for this Ligand-Target Pair

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Macrophage-stimulating protein receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 8.99E+3nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Non-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 9.44E+3nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Tyrosine-protein kinase Blk(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Carbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
University Of Tampere And Tampere University Hospital

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Ki: 1.49E+4nMAssay Description:Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 0.330nMAssay Description:Inhibition of Bcr-Abl kinase (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 0.5nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 1nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair

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Details PubMed PDB

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 1.20nMAssay Description:Inhibition of recombinant human N-terminal His-tagged Abl (2 to 1130 residues) expressed in baculovirus expression system using FAM-labelled P2 pepti...More data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair

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Epithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 3.70nMAssay Description:Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 5.20nMAssay Description:Inhibition of autophosphorylation of DDR2 expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 5.60nMAssay Description:Inhibition of human ABL1 assessed as residual activity using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 13nMAssay Description:Inhibition of wild type BCR/Abl (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 hrs ...More data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 14nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 15nMAssay Description:Inhibition of human c-Kit using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 19nMAssay Description:Inhibition of ABL1 (unknown origin)More data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 20nMAssay Description:Inhibition of autophosphorylation of BCR-ABL1 expressed in Ba/F cellsMore data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 24nMAssay Description:Inhibition of BCR/Abl M351T mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 h...More data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 25nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDGFRbeta cytoplasmic domain (557 to 1106 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 28nMAssay Description:Inhibition of kinobead binding to ABL in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: <30nMAssay Description:Inhibition of BCR-Abl (unknown origin)More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 30nMAssay Description:Inhibition of full-length N-terminal His-tagged human c-Abl kinase (2 to 1130 residues) expressed in baculovirus expression system using Tk-substrate...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 30nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: <30nMAssay Description:Inhibition of Bcr-Abl (unknown origin)More data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 31nMAssay Description:Inhibition of BCR/Abl F317I mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 h...More data for this Ligand-Target Pair

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Epithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 33nMAssay Description:Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...More data for this Ligand-Target Pair

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Ephrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 33nMAssay Description:Refer to Reaction Biology Corps.More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 33nMAssay Description:TBDMore data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 37nMAssay Description:Inhibition of BCR/Abl Q252H mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 h...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 38nMAssay Description:Inhibition of wild type AblMore data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 39.3nMAssay Description:Inhibition of Bcr/Abl by FRET-based Z-lyte assayMore data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 42nMAssay Description:Inhibition of BCR-ABL1 autophosphorylation in human K562 cellsMore data for this Ligand-Target Pair

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Epithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 43nMAssay Description:Inhibition of DDR1b (unknown origin) assessed as reduction in collagen-induced DDR1b activationMore data for this Ligand-Target Pair

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Epithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 43nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 44nMAssay Description:Inhibition of human recombinant wild type ABL1 expressed in insect cells after 30 mins by FRET assayMore data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 55nMAssay Description:Inhibition of DDR2 (unknown origin) assessed as reduction in collagen-induced DDR2 activationMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 60nMAssay Description:Inhibition of human PDGFRbeta using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 71nMAssay Description:Inhibition of PDGFRbeta autophosphorylation in human A31 cells by ELISAMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 71nMAssay Description:Inhibition of human PDGFRalpha autophosphorylation in human A31 cells by ELISAMore data for this Ligand-Target Pair

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Epithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: <100nMAssay Description:Inhibition of kinobead binding to DDR1 in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 105nMAssay Description:Inhibition of DDR2 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...More data for this Ligand-Target Pair

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Tyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 108nMAssay Description:Inhibition of human LCK using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 120nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 126nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 158nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged c-Kit (544 to end residues) expressed in baculovirus infected Sf21 insect cells using FAM-label...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 158nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair

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Breakpoint cluster region protein [1-693](Homo sapiens (Human))
Xi'An Jiaotong University

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 214nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 217nMAssay Description:Inhibition of human KIT autophosphorylation in human GIST882 cells by ELISAMore data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 347nMAssay Description:Inhibition of BCR/Abl Y253F mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as inhibition of cell proliferation measured after 72 h...More data for this Ligand-Target Pair

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Ribosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 381nMAssay Description:Inhibition of full length human His6/GST-tagged NQO2 expressed in Escherichia coli Tuner(DE3)pLysS using menadione as substrate and CCHP as co-substr...More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 450nMAssay Description:Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Chung-Ang University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 534nMAssay Description:Inhibition of CSF1R in mouse MNFS-60 cells assessed as reduction in CSF-induced cell viability after 48 hrs by Ez-cytox reagent based assayMore data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 580nMAssay Description:Inhibition of human recombinant CYP3A4 expressed in insect cell microsomes in presence of NADPH by fluorescence assayMore data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 677nMAssay Description:Inhibition of autophosphorylation of CSF1R expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: >700nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: >1.00E+3nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 1.10E+3nMAssay Description:Inhibition of Raf1 kinaseMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Lyn(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 1.28E+3nMAssay Description:Inhibition of human LYN using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair

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Ribosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 1.80E+3nMAssay Description:Inhibition of kinobead binding to NQO2 in human K562 cells incubated for 30 mins by iTRAQ reagent-based mass spectrometric methodMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 1.90E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged SRC (1 to 536 residues) expressed in baculovirus expression system using FAM-labell...More data for this Ligand-Target Pair

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Broad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 2.50E+3nMAssay Description:Inhibition of human ABCG2 expressed in human HEK293 cells membrane vesicles mediated transport of 3[H]-MTX for 1 hr using [3H]-methotrexate as substr...More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
Chantest

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 4.70E+3nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
Ariad Pharmaceuticals

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: >5.00E+3nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 9.17E+3nMAssay Description:Inhibition of ABL1 T315I mutant (unknown origin)More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 9.55E+3nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK peptide substrateMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 6.31E+4nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 2.00E+5nMAssay Description:Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automa...More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 3.98E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair

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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 1.00E+6nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 3.16E+6nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

IC50: 5.01E+6nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair

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Ferrochelatase, mitochondrial [R115L](Homo sapiens (Human))
Technical University Of Munich

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.70E+3nMAssay Description:Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1 [229-512](Homo sapiens (Human))
Stony Brook University

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 11nMAssay Description:Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1 [229-512](Homo sapiens (Human))
Stony Brook University

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 15nMAssay Description:Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against phospho...More data for this Ligand-Target Pair

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Ephrin type-A receptor 2 [596-900](Homo sapiens (Human))
Technical University Of Munich

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 415nMAssay Description:Kinobeads competition assays were performed in 96-well format as previously described using mixed protein lysates of four cancer cell lines (K-562, M...More data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 6nMAssay Description:Binding affinity to wild type DDR2 (unknown origin) by FLiK assayMore data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 75nMAssay Description:Binding affinity to human acrylodan-labeled N-terminal His-tagged DDR2 (558 to 855 aa) by FLiK assayMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair

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SRSF protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(G719C) kinase domainMore data for this Ligand-Target Pair

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Rho-associated protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ROCK2 kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(L858R) kinase domainMore data for this Ligand-Target Pair

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cGMP-dependent protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKG1 kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-E749del, A750P) kinase domainMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RET(V804M) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 56nMAssay Description:Binding constant for ABL1(F317I)-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Hepatocyte growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MET kinase domainMore data for this Ligand-Target Pair

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KEGG
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Mitogen-activated protein kinase kinase kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP3K4 kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-T751del,Sins) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 770nMAssay Description:Binding constant for KIT(D816V) kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.70E+3nMAssay Description:Binding constant for BRAF kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 17A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DRAK1 kinase domainMore data for this Ligand-Target Pair

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Myosin-IIIb(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MYO3B kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase TNNI3K(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 360nMAssay Description:Binding constant for TNNI3K kinase domainMore data for this Ligand-Target Pair

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Hepatocyte growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MET(M1250T) kinase domainMore data for this Ligand-Target Pair

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Inhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for IKK-alpha kinase domainMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 29nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair

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MAP/microtubule affinity-regulating kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MARK3 kinase domainMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
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BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT3(D835Y) kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
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Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(S752-I759del) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
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BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ABL1(T315I)-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(M1043I) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
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BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 13nMAssay Description:Binding constant for ABL1(Y253F)-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
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Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(L861Q) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
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BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 13nMAssay Description:Binding constant for ABL1-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
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BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 10nMAssay Description:Binding constant for ABL1(Q252H)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair

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Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LRRK2 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
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BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 15nMAssay Description:Binding constant for ABL1(M351T)-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Misshapen-like kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MINK kinase domainMore data for this Ligand-Target Pair

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Ephrin type-A receptor 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 590nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 870nMAssay Description:Binding constant for RET kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
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BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 660nMAssay Description:Binding constant for ABL1(T315I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair

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Macrophage-stimulating protein receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MST1R kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(H1047L) kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA kinase domainMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
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Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair

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KEGG
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Serine/threonine-protein kinase MRCK gamma(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DMPK2 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK4-cyclinD1 kinase domainMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RET(V804L) kinase domainMore data for this Ligand-Target Pair

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Death-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DAPK1 kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
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Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 260nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair

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Myotonin-protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DMPK kinase domainMore data for this Ligand-Target Pair

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eIF-2-alpha kinase GCN2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for GCN2(Kin.Dom.2,S808G) kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(G719S) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase JAK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for JAK1(JH2domain-pseudokinase) kinase domainMore data for this Ligand-Target Pair

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Non-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
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Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TYK2(JH2domain-pseudokinase) kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase BRSK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BRSK1 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(C420R) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
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Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 4.90nMAssay Description:Binding constant for ABL1(H396P)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Ribosomal protein S6 kinase alpha-4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair

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Insulin receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for INSR kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(Q546K) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 18nMAssay Description:Binding constant for ABL1(F317I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(H1047Y) kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 11A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDC2L2 kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 22nMAssay Description:Binding constant for KIT(L576P) kinase domainMore data for this Ligand-Target Pair

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Protein kinase C eta type(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKCH kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 540nMAssay Description:Binding constant for KIT(D816H) kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(E746-A750del) kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMK2B kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 46nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair

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Myosin light chain kinase, smooth muscle(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(E545A) kinase domainMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair

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Ephrin type-A receptor 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 640nMAssay Description:Binding constant for EPHA6 kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 12nMAssay Description:Binding constant for ABL1(F317L)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase D2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKD2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CHEK1 kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMKK2 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(E545K) kinase domainMore data for this Ligand-Target Pair

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AP2-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AAK1 kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 150nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT3(K663Q) kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(T790M) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 10nMAssay Description:Binding constant for ABL1-nonphosphorylated kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(L858R,T790M) kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(I800L) kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 21nMAssay Description:Binding constant for ABL1(Q252H)-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT3(D835H) kinase domainMore data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT4 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 36nMAssay Description:Binding constant for ABL1(E255K)-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 21nMAssay Description:Binding constant for ABL1(H396P)-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair

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Interleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for IRAK3 kinase domainMore data for this Ligand-Target Pair

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Aurora kinase B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AURKB kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 14(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 460nMAssay Description:Binding affinity to P38-alpha (unknown origin)More data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair

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Activated CDC42 kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TNK2 kinase domainMore data for this Ligand-Target Pair

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High affinity nerve growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TRKA kinase domainMore data for this Ligand-Target Pair

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Myosin light chain kinase family member 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MYLK4 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PAK4 kinase domainMore data for this Ligand-Target Pair

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KEGG
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Serine/threonine-protein kinase SBK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SBK1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase DCLK2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DCAMKL2 kinase domainMore data for this Ligand-Target Pair

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Receptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERBB4 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 890nMAssay Description:Binding constant for HPK1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase N2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PKN2 kinase domainMore data for this Ligand-Target Pair

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Protein kinase C theta type(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKCQ kinase domainMore data for this Ligand-Target Pair

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cGMP-dependent protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKG2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MST2 kinase domainMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Serine/threonine-protein kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MST1 kinase domainMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Dual specificity testis-specific protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TESK1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TYRO3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase VRK2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for VRK2 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DLK kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 25(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for YSK1 kinase domainMore data for this Ligand-Target Pair

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NCI pathway KEGG
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Mitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP4K5 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP3K2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PLK2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PLK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase pim-2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIM2 kinase domainMore data for this Ligand-Target Pair

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Citron Rho-interacting kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CIT kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 38(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NDR1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Nek1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase tousled-like 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TLK1 kinase domainMore data for this Ligand-Target Pair

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KEGG
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Cyclin-dependent kinase 14(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PFTK1 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIP5K1C kinase domainMore data for this Ligand-Target Pair

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STE20/SPS1-related proline-alanine-rich protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for STK39 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase TBK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TBK1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Sgk3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SGK3 kinase domainMore data for this Ligand-Target Pair

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Inhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for IKK-epsilon kinase domainMore data for this Ligand-Target Pair

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Insulin receptor-related protein(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for INSRR kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PLK4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PLK4 kinase domainMore data for this Ligand-Target Pair

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Death-associated protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DAPK2 kinase domainMore data for this Ligand-Target Pair

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SRSF protein kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SRPK3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Nek6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK6 kinase domainMore data for this Ligand-Target Pair

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Eukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EIF2AK1 kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase LATS2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LATS2 kinase domainMore data for this Ligand-Target Pair

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KEGG
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Hormonally up-regulated neu tumor-associated kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for HUNK kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ULK2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ULK2 kinase domainMore data for this Ligand-Target Pair

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STE20-like serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SLK kinase domainMore data for this Ligand-Target Pair

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Maternal embryonic leucine zipper kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MELK kinase domainMore data for this Ligand-Target Pair

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NUAK family SNF1-like kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ARK5 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ICK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ICK kinase domainMore data for this Ligand-Target Pair

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Microtubule-associated serine/threonine-protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAST1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 38-like(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NDR2 kinase domainMore data for this Ligand-Target Pair

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TRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TNIK kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 19(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK11 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase SIK2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SIK2 kinase domainMore data for this Ligand-Target Pair

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NCI pathway KEGG
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Serine/threonine-protein kinase 36(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for STK36 kinase domainMore data for this Ligand-Target Pair

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Interleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for IRAK4 kinase domainMore data for this Ligand-Target Pair

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PDB
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Serine/threonine-protein kinase TAO2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TAOK2 kinase domainMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Serine/threonine-protein kinase NLK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NLK kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase TAO3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.70E+3nMAssay Description:Binding constant for TAOK3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 26(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MST4 kinase domainMore data for this Ligand-Target Pair

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Myosin-IIIa(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MYO3A kinase domainMore data for this Ligand-Target Pair

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Ephrin type-B receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 640nMAssay Description:Binding constant for EPHB2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase MARK2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MARK2 kinase domainMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MKNK2 kinase domainMore data for this Ligand-Target Pair

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BMP-2-inducible protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BIKE kinase domainMore data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TRPM6 kinase domainMore data for this Ligand-Target Pair

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SNF-related serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SNRK kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase RIO2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RIOK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 32B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for YANK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase MARK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MARK1 kinase domainMore data for this Ligand-Target Pair

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Glycogen synthase kinase-3 alpha(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for GSK3A kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PAK 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PAK6 kinase domainMore data for this Ligand-Target Pair

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Atypical kinase COQ8A, mitochondrial(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ADCK3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PAK 5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PAK7 kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMK1D kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type 1G(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMK1G kinase domainMore data for this Ligand-Target Pair

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Ephrin type-A receptor 8(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 37nMAssay Description:Binding constant for EPHA8 kinase domainMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.10E+3nMAssay Description:Binding constant for RET(M918T) kinase domainMore data for this Ligand-Target Pair

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Receptor-interacting serine/threonine-protein kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RIPK4 kinase domainMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 7.10E+3nMAssay Description:Binding constant for CLK4 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase TAO1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 4.70E+3nMAssay Description:Binding constant for TAOK1 kinase domainMore data for this Ligand-Target Pair

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Casein kinase I isoform gamma-1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK1G1 kinase domainMore data for this Ligand-Target Pair

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Homeodomain-interacting protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FGFR4 kinase domainMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 8.80E+3nMAssay Description:Binding constant for PIP5K2C kinase domainMore data for this Ligand-Target Pair

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Atypical kinase COQ8B, mitochondrial(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ADCK4 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for YSK4 kinase domainMore data for this Ligand-Target Pair

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Dual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 33(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for STK33 kinase domainMore data for this Ligand-Target Pair

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NUAK family SNF1-like kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SNARK kinase domainMore data for this Ligand-Target Pair

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MAP/microtubule affinity-regulating kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MARK4 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase RIO1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RIOK1 kinase domainMore data for this Ligand-Target Pair

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Testis-specific serine/threonine-protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TSSK1B kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMKK1 kinase domainMore data for this Ligand-Target Pair

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Wee1-like protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for WEE2 kinase domainMore data for this Ligand-Target Pair

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Uncharacterized serine/threonine-protein kinase SBK3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SgK110 kinase domainMore data for this Ligand-Target Pair

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Dual serine/threonine and tyrosine protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RIPK5 kinase domainMore data for this Ligand-Target Pair

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Calcium-dependent protein kinase 1(Plasmodium Falciparum)
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 790nMAssay Description:Binding constant for PFCDPK1(P.falciparum) kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 2 homolog(Plasmodium falciparum (isolate 3D7))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PFPK5(P.falciparum) kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 32C(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for YANK3 kinase domainMore data for this Ligand-Target Pair

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Ankyrin repeat and protein kinase domain-containing protein 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ANKK1 kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RPS6KA5(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair

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Ephrin type-A receptor 5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.90E+3nMAssay Description:Binding constant for EPHA5 kinase domainMore data for this Ligand-Target Pair

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Myosin light chain kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MLCK kinase domainMore data for this Ligand-Target Pair

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Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PKMYT1 kinase domainMore data for this Ligand-Target Pair

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Leucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LRRK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Nek5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK5 kinase domainMore data for this Ligand-Target Pair

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Leukocyte tyrosine kinase receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ZAP70 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase N1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase CSK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 2.40E+3nMAssay Description:Binding constant for CSK kinase domainMore data for this Ligand-Target Pair

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Casein kinase I isoform gamma-3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK1G3 kinase domainMore data for this Ligand-Target Pair

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Ephrin type-A receptor 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 230nMAssay Description:Binding constant for EPHA2 kinase domainMore data for this Ligand-Target Pair

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Ephrin type-A receptor 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 330nMAssay Description:Binding constant for EPHA4 kinase domainMore data for this Ligand-Target Pair

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Ephrin type-A receptor 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EPHA7 kinase domainMore data for this Ligand-Target Pair

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Ephrin type-B receptor 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.30E+3nMAssay Description:Binding constant for EPHB1 kinase domainMore data for this Ligand-Target Pair

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Ephrin type-B receptor 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.00E+3nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair

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Ephrin type-B receptor 4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 730nMAssay Description:Binding constant for EPHB4 kinase domainMore data for this Ligand-Target Pair

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Ephrin type-B receptor 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 500nMAssay Description:Binding constant for EPHB6 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3C2G kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP4K2 kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 14(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TGFBR1 kinase domainMore data for this Ligand-Target Pair

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KEGG
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Mitogen-activated protein kinase kinase kinase 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ASK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase LATS1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LATS1 kinase domainMore data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DYRK1B kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 13(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LZK kinase domainMore data for this Ligand-Target Pair

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PDB MMDB KEGG
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Serine/threonine-protein kinase DCLK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DCAMKL1 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK5 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MTOR kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for JAK2(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CD kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PLK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PLK1 kinase domainMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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cAMP-dependent protein kinase catalytic subunit PRKX(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase OSR1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for OSR1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 14nMAssay Description:Binding constant for ABL1(F317L)-phosphorylated kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 26nMAssay Description:Binding constant for ABL2 kinase domainMore data for this Ligand-Target Pair

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RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AKT1 kinase domainMore data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 45nMAssay Description:Binding constant for CSF1R kinase domainMore data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-S752del, P753S) kinase domainMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 2.10E+3nMAssay Description:Binding constant for CLK1 kinase domainMore data for this Ligand-Target Pair

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NT-3 growth factor receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 600nMAssay Description:Binding constant for TRKC kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 12(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for p38-gamma kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Mer(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MERTK kinase domainMore data for this Ligand-Target Pair

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PDB NCI pathway KEGG
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Aurora kinase C(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AURKC kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type II subunit delta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMK2D kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase tousled-like 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TLK2 kinase domainMore data for this Ligand-Target Pair

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PDB Reactome pathway
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5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AMPK-alpha1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase SIK3 [59-1321](Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for QSK kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 16(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for STK16 kinase domainMore data for this Ligand-Target Pair

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KEGG
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Cyclin-dependent kinase 17(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PCTK2 kinase domainMore data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 33nMAssay Description:Binding constant for DDR2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ACVRL1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase BTK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BTK kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK4-cyclinD1 kinase domainMore data for this Ligand-Target Pair

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Fibroblast growth factor receptor 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FGFR3 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase JAK3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for JAK3(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 46nMAssay Description:Binding constant for KIT(A829P) kinase domainMore data for this Ligand-Target Pair

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Hepatocyte growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MET(M1250T) kinase domainMore data for this Ligand-Target Pair

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Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PHKG2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase STK11(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LKB1 kinase domainMore data for this Ligand-Target Pair

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Angiopoietin-1 receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.00E+3nMAssay Description:Binding constant for TIE2 kinase domainMore data for this Ligand-Target Pair

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Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for IGF1R kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 15(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP3K15 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase pim-3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIM3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Chk2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CHEK2 kinase domainMore data for this Ligand-Target Pair

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Receptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERBB2 kinase domainMore data for this Ligand-Target Pair

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MAP kinase-activated protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAPKAPK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Nek9(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK9 kinase domainMore data for this Ligand-Target Pair

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Myosin light chain kinase 2, skeletal/cardiac muscle(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MYLK2 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MLK1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase DCLK3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DCAMKL3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PKNB(M.tuberculosis) kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 11B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDC2L1 kinase domainMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Tyrosine-protein kinase Srms(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SRMS kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 35(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for STK35 kinase domainMore data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DYRK1A kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Nek7(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK7 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 11nMAssay Description:Binding constant for ZAK kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 14(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 460nMAssay Description:Binding constant for p38-alpha kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 15(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERK8 kinase domainMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Casein kinase I isoform delta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK1D kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 9(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 5.80E+3nMAssay Description:Binding constant for JNK2 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 15(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PFTAIRE2 kinase domainMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Rhodopsin kinase GRK7(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for GRK7 kinase domainMore data for this Ligand-Target Pair

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Homeodomain-interacting protein kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair

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Dual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 190nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair

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Dual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MKK7 kinase domainMore data for this Ligand-Target Pair

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Casein kinase I isoform alpha-like(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK1A1L kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TAK1 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP4K4 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Nek11(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK11 kinase domainMore data for this Ligand-Target Pair

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Homeodomain-interacting protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for HIPK1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Fyn(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.60E+3nMAssay Description:Binding constant for FYN kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase NIM1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NIM1 kinase domainMore data for this Ligand-Target Pair

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Focal adhesion kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FAK kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type II subunit gamma(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMK2G kinase domainMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Protein-tyrosine kinase 2-beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PYK2 kinase domainMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Serine/threonine-protein kinase SIK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SIK kinase domainMore data for this Ligand-Target Pair

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Ephrin type-A receptor 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 110nMAssay Description:Binding constant for EPHA3 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Fer(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FER kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Fgr(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 320nMAssay Description:Binding constant for FGR kinase domainMore data for this Ligand-Target Pair

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Cyclin-G-associated kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 47nMAssay Description:Binding constant for LCK kinase domainMore data for this Ligand-Target Pair

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Protein kinase C epsilon type(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKCE kinase domainMore data for this Ligand-Target Pair

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Rho-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.90E+3nMAssay Description:Binding constant for SRC kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase receptor Tie-1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.00E+3nMAssay Description:Binding constant for TIE1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Yes(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.10E+3nMAssay Description:Binding constant for YES kinase domainMore data for this Ligand-Target Pair

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RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ITK kinase domainMore data for this Ligand-Target Pair

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LIM domain kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LIMK2 kinase domainMore data for this Ligand-Target Pair

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Muscle, skeletal receptor tyrosine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair

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Homeodomain-interacting protein kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for HIPK3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase D3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKD3 kinase domainMore data for this Ligand-Target Pair

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KEGG
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Serine/threonine-protein kinase MAK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAK kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP3K1 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ASK1 kinase domainMore data for this Ligand-Target Pair

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Protein-tyrosine kinase 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BRK kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 10(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 6.80E+3nMAssay Description:Binding constant for LOK kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 910nMAssay Description:Binding constant for MRCKB kinase domainMore data for this Ligand-Target Pair

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BDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 490nMAssay Description:Binding constant for TRKB kinase domainMore data for this Ligand-Target Pair

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PDB
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Cyclin-dependent kinase 16(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PCTK1 kinase domainMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 180nMAssay Description:Binding constant for PDGFRA kinase domainMore data for this Ligand-Target Pair

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Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PHKG1 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CB kinase domainMore data for this Ligand-Target Pair

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PDB Reactome pathway
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5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AMPK-alpha2 kinase domainMore data for this Ligand-Target Pair

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Protein kinase C delta type(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKCD kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ULK3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ULK3 kinase domainMore data for this Ligand-Target Pair

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Activin receptor type-1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ACVR1 kinase domainMore data for this Ligand-Target Pair

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Activin receptor type-2B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ACVR2B kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 32A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for YANK1 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase-like 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDKL3 kinase domainMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MKNK1 kinase domainMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIP5K1A kinase domainMore data for this Ligand-Target Pair

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PDB
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Bone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BMPR1B kinase domainMore data for this Ligand-Target Pair

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Bone morphogenetic protein receptor type-2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BMPR2 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK3 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 8(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK8 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 9(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK9 kinase domainMore data for this Ligand-Target Pair

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Casein kinase I isoform gamma-2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK1G2 kinase domainMore data for this Ligand-Target Pair

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Death-associated protein kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DAPK3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERN1 kinase domainMore data for this Ligand-Target Pair

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Inhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for IKK-beta kinase domainMore data for this Ligand-Target Pair

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Interleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for IRAK1 kinase domainMore data for this Ligand-Target Pair

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Activin receptor type-2A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ACVR2A kinase domainMore data for this Ligand-Target Pair

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PDB Reactome pathway
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RAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AKT2 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AXL kinase domainMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Tyrosine-protein kinase Blk(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 500nMAssay Description:Binding constant for BLK kinase domainMore data for this Ligand-Target Pair

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Cytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BMX kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type IV(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMK4 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK2 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 7(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDK7 kinase domainMore data for this Ligand-Target Pair

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Casein kinase I isoform alpha(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK1A1 kinase domainMore data for this Ligand-Target Pair

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Casein kinase I isoform epsilon(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK1E kinase domainMore data for this Ligand-Target Pair

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Casein kinase II subunit alpha(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK2A1 kinase domainMore data for this Ligand-Target Pair

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Casein kinase II subunit alpha'(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CSNK2A2 kinase domainMore data for this Ligand-Target Pair

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Epithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 1.10nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair

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Receptor tyrosine-protein kinase erbB-3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Fes/Fps(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FES kinase domainMore data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase FRK(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 86nMAssay Description:Binding constant for FRK kinase domainMore data for this Ligand-Target Pair

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase HCK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 390nMAssay Description:Binding constant for HCK kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase JAK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for JAK1(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for VEGFR2 kinase domainMore data for this Ligand-Target Pair

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LIM domain kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for LIMK1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Lyn(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 100nMAssay Description:Binding constant for LYN kinase domainMore data for this Ligand-Target Pair

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Megakaryocyte-associated tyrosine-protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CTK kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP3K3 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MLK3 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MLK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PAK 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PAK 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PAK3 kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 18 [3-474](Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PCTK3 kinase domainMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 73nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair

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3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3C2B kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIM1 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CG kinase domainMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Phosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK4CB kinase domainMore data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PKAC-alpha kinase domainMore data for this Ligand-Target Pair

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cAMP-dependent protein kinase catalytic subunit beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PKAC-beta kinase domainMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Protein kinase C iota type(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKCI kinase domainMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Serine/threonine-protein kinase D1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKD1 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERK1 kinase domainMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
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Mitogen-activated protein kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERK4 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERK3 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 7(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ERK5 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 8(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 450nMAssay Description:Binding constant for JNK1 kinase domainMore data for this Ligand-Target Pair

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Mitogen-activated protein kinase 11(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 36nMAssay Description:Binding constant for p38-beta kinase domainMore data for this Ligand-Target Pair

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Details Article PubMed MMDB

Mitogen-activated protein kinase 10(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 2.00E+3nMAssay Description:Binding constant for JNK3 kinase domainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Mitogen-activated protein kinase 13(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for p38-delta kinase domainMore data for this Ligand-Target Pair

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Dual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Dual specificity mitogen-activated protein kinase kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MEK3 kinase domainMore data for this Ligand-Target Pair

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Dual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MEK6 kinase domainMore data for this Ligand-Target Pair

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Interferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRKR kinase domainMore data for this Ligand-Target Pair

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RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 3.90E+3nMAssay Description:Binding constant for RAF1 kinase domainMore data for this Ligand-Target Pair

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PDB NCI pathway Reactome pathway KEGG
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Rhodopsin kinase GRK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for GRK1 kinase domainMore data for this Ligand-Target Pair

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PDB KEGG
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Proto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ROS1 kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair

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Dual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair

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PDB MMDB KEGG
UniProtKB/SwissProt
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SRSF protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SRPK1 kinase domainMore data for this Ligand-Target Pair

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KEGG
UniProtKB/SwissProt
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Serine/threonine-protein kinase Nek4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK4 kinase domainMore data for this Ligand-Target Pair

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PDB KEGG
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Cyclin-dependent kinase-like 5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDKL5 kinase domainMore data for this Ligand-Target Pair

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Ribosomal protein S6 kinase beta-1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for S6K1 kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for SYK kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Tec(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TEC kinase domainMore data for this Ligand-Target Pair

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TGF-beta receptor type-2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TGFBR2 kinase domainMore data for this Ligand-Target Pair

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Dual specificity protein kinase TTK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TTK kinase domainMore data for this Ligand-Target Pair

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Tyrosine-protein kinase TXK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TXK kinase domainMore data for this Ligand-Target Pair

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Non-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TYK2(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair

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Wee1-like protein kinase(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for WEE1 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 5-phosphate 4-kinase type-2 beta(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIP5K2B kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase ULK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ULK1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 24(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MST3 kinase domainMore data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DYRK2 kinase domainMore data for this Ligand-Target Pair

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Aurora kinase A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for AURKA kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MRCKA kinase domainMore data for this Ligand-Target Pair

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PDB NCI pathway KEGG
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Mitogen-activated protein kinase kinase kinase kinase 3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAP4K3 kinase domainMore data for this Ligand-Target Pair

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Calcium/calmodulin-dependent protein kinase type 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair

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MAP kinase-activated protein kinase 5(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for MAPKAPK5 kinase domainMore data for this Ligand-Target Pair

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Peripheral plasma membrane protein CASK(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CASK kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 13(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDC2L5 kinase domainMore data for this Ligand-Target Pair

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Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RIPK1 kinase domainMore data for this Ligand-Target Pair

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Receptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RIPK2 kinase domainMore data for this Ligand-Target Pair

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Reactome pathway KEGG
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Serine/threonine-protein kinase RIO3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RIOK3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PRP4 homolog(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PRP4 kinase domainMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
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Ribosomal protein S6 kinase alpha-4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase-like 2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDKL2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BRSK2 kinase domainMore data for this Ligand-Target Pair

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Non-receptor tyrosine-protein kinase TNK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for TNK1 kinase domainMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CLK3 kinase domainMore data for this Ligand-Target Pair

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Dual specificity protein kinase CLK2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CLK2 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PLK3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PLK3 kinase domainMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for FLT3(R834Q) kinase domainMore data for this Ligand-Target Pair

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Cyclin-dependent kinase-like 1 [2-358](Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for CDKL1 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase 17B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for DRAK2 kinase domainMore data for this Ligand-Target Pair

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Activin receptor type-1B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ACVR1B kinase domainMore data for this Ligand-Target Pair

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ALK tyrosine kinase receptor(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for ALK kinase domainMore data for this Ligand-Target Pair

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Bone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for BMPR1A kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 570nMAssay Description:Binding constant for BRAF(V600E) kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase Nek2(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK2 kinase domainMore data for this Ligand-Target Pair

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KEGG
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Serine/threonine-protein kinase Nek3(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for NEK3 kinase domainMore data for this Ligand-Target Pair

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Serine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PAK1 kinase domainMore data for this Ligand-Target Pair

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G protein-coupled receptor kinase 4(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(E542K) kinase domainMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 16nMAssay Description:Binding affinity to human PDGFRbeataMore data for this Ligand-Target Pair

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Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 74nMAssay Description:Binding affinity to human PDGFRalphaMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 4.00E+4nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair

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Discoidin domain-containing receptor 2(Homo sapiens (Human))
Massachusetts General Hospital And Harvard Medical School

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 6.20nMAssay Description:Binding affinity to human DDR2More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 17nMAssay Description:Binding affinity to human c-KitMore data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 3.60nMAssay Description:Binding affinity to human ABL1More data for this Ligand-Target Pair

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PDB MMDB KEGG
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B.MOAD antibodypedia GoogleScholar

Dual specificity protein kinase CLK1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 2.10E+3nMAssay Description:Binding affinity to full length recombinant human CLK1 (M1 to I484 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by PDSP K_i Database

BDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)

Kd: 4.90nMAssay Description:Binding affinity to ABL1 (unknown origin)More data for this Ligand-Target Pair

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