Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50201047((1S,6R)-3-(5-methyl-pyridin-3-yl)-3,8-diaza-bicycl...)Copy SMILESCopy InChI

Affinity DataEC50:  650nMAssay Description:Agonist activity at human alpha4beta2 ACHR expressed in HEK293 cells assessed as change in intracellular calcium concentration by FLIPRMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL

LigandBDBM50201047((1S,6R)-3-(5-methyl-pyridin-3-yl)-3,8-diaza-bicycl...)Copy SMILESCopy InChI

Affinity DataEC50:  1.41E+3nMAssay Description:Agonist activity against human alpha3beta4 nAChRMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Burnham Institute For Medical Research

Curated by ChEMBL

LigandBDBM50201047((1S,6R)-3-(5-methyl-pyridin-3-yl)-3,8-diaza-bicycl...)Copy SMILESCopy InChI

Affinity DataEC50:  646nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI