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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by
ChEMBL
Ligand
BDBM50442525
(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
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Affinity Data
Ki: 6.80nM
Assay Description:
Displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor allosteric binding site (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by
ChEMBL
Ligand
BDBM50442525
(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 23nM
Assay Description:
The utility of the compounds in accordance with the present invention as negative allosteric modulators of metabotropic glutamate receptor activity, ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science
Curated by
ChEMBL
Ligand
BDBM50442525
(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
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Affinity Data
IC50: 24nM
Assay Description:
Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science
Curated by
ChEMBL
Ligand
BDBM50442525
(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 24nM
Assay Description:
Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
Vanderbilt University Institute Of Imaging Science
Curated by
ChEMBL
Ligand
BDBM50442525
(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 25nM
Assay Description:
The utility of the compounds in accordance with the present invention as negative allosteric modulators of metabotropic glutamate receptor activity, ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by
ChEMBL
Ligand
BDBM50442525
(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 26nM
Assay Description:
Inhibition of mGluR5 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by
ChEMBL
Ligand
BDBM50442525
(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 49nM
Assay Description:
Allosteric modulation of human mGlu5 receptor expressed in HEK cells assessed as effect on glutamate-induced calcium mobilization
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Vanderbilt University Institute Of Imaging Science
Curated by
ChEMBL
Ligand
BDBM50442525
(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
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Affinity Data
IC50: <100nM
Assay Description:
Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI