Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50439640(CHEMBL2419606 | US8993586, 57)
Affinity DataIC50:  13nMAssay Description:Preparation of rhACC2. Human ACC2 inhibition was measured using purified recombinant human ACC2 (hrACC2). Briefly, a full length Cytomax clone of ACC...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50439640(CHEMBL2419606 | US8993586, 57)
Affinity DataIC50:  16nMAssay Description:Inhibition of human ACC2 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50439640(CHEMBL2419606 | US8993586, 57)
Affinity DataIC50:  49nMAssay Description:Inhibition of human ACC1 using acetyl-CoA as substrate assessed as [14C]malonyl-CoA synthesis preincubated for 10 mins prior to substrate addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50439640(CHEMBL2419606 | US8993586, 57)
Affinity DataIC50:  50nMpH: 7.5Assay Description:Preparation of rhACC1. Two liters of SF9 cells, infected with recombinant baculovirus containing full length human ACC1 cDNA, were suspended in ice-c...More data for this Ligand-Target Pair
In DepthDetails US Patent