Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 18 hits in this display   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50: <100nMAssay Description:LSD1: A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50: <100nMpH: 8.0 T: 2°CAssay Description:A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50: <100nMAssay Description:LSD1: A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50: <100nMpH: 8.0 T: 2°CAssay Description:A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50: <100nMpH: 8.0 T: 2°CAssay Description:A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50: <100nMAssay Description:A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  6.10E+4nMpH: 7.5 T: 2°CAssay Description:The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  6.10E+4nMpH: 7.5 T: 2°CAssay Description:The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  6.10E+4nMpH: 7.5 T: 2°CAssay Description:A test compound dissolved in DMSO was added to a reaction solution (100 mM HEPES (pH 7.5), 5% glycerol) containing MAO-A enzyme (Sigma-Aldrich Co. LL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  6.10E+4nMAssay Description:The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  6.10E+4nMAssay Description:MAO-A: The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  6.10E+4nMAssay Description:A test compound dissolved in DMSO was added to a reaction solution (100 mM HEPES (pH 7.5), 5% glycerol) containing MAO-A enzyme (Sigma-Aldrich Co. LL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  9.60E+4nMpH: 7.5 T: 2°CAssay Description:A test compound dissolved in DMSO was added to a reaction solution (100 mM HEPES (pH 7.5), 5% glycerol, 10% DMSO) containing MAO-B enzyme (Sigma-Aldr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  9.60E+4nMAssay Description:The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  9.60E+4nMAssay Description:A test compound dissolved in DMSO was added to a reaction solution (100 mM HEPES (pH 7.5), 5% glycerol, 10% DMSO) containing MAO-B enzyme (Sigma-Aldr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  9.60E+4nMAssay Description:MAO-B: The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  9.60E+4nMpH: 7.5 T: 2°CAssay Description:The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM243419(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Affinity DataIC50:  9.60E+4nMpH: 7.5 T: 2°CAssay Description:The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent