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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetMonoglyceride lipase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180074(US9133148, 10c)
Affinity DataIC50:  230nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180074(US9133148, 10c)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of PLA2G7 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180074(US9133148, 10c)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of ABHD6 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Mus musculus (mouse))
The Scripps Research Institute

US Patent
LigandPNGBDBM180074(US9133148, 10c)
Affinity DataIC50: >6.25E+3nMT: 2°CAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 uL, 1.0 mg/mL total protein concentration) were preincubated with varying concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent