Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 34 hits in this display   

TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4nMAssay Description:Inhibition of DPP1 in human U937 cells using Gly-Phe-AFC as substrate preincubated for 60 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of amino methyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  4.47nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as substrate pretreated for 1 hr followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as substrate pretreated for 1 hr followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Canis lupus familiaris)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  16nMAssay Description:Inhibition of dog DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition incubated for 60 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition and incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 1(Rattus norvegicus)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  20nMAssay Description:Inhibition of rat DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Mus musculus)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  25nMAssay Description:Inhibition of mouse DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  62nMAssay Description:Inhibition of DPP1 in human primary bone marrow-derived CD34+ neutrophil progenitor cells assessed as inactivation of neutrophil elastase using metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  115nMAssay Description:Inhibition of DPP1 in human primary bone marrow-derived CD34+ neutrophil progenitor cells assessed as inactivation of cathepsin G using N-succinyl-Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  141nMAssay Description:Inhibition of DPP1 in human primary bone marrow-derived CD34+ neutrophil progenitor cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50:  209nMAssay Description:Inhibition of DPP1 in human primary bone marrow-derived CD34+ neutrophil progenitor cells assessed as inactivation of proteinase 3 using aminobenzoyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataKd:  2.5nMAssay Description:Reversible inhibition of human recombinant DPP1 by surface plasmon resonance direct binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed