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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50059307
(CHEMBL3393439 | US9156845, 1)
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Affinity Data
IC50: 12nM
Assay Description:
Inhibition of GST-tagged truncated human recombinant LRRK2 using fluorescein-labeled LRRKtide peptide substrate incubated for 2 hrs
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50059307
(CHEMBL3393439 | US9156845, 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 13nM
pH: 7.5
Assay Description:
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S]
(Homo sapiens (Human))
Pfizer
US Patent
Ligand
BDBM50059307
(CHEMBL3393439 | US9156845, 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 36nM
pH: 7.5
Assay Description:
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50059307
(CHEMBL3393439 | US9156845, 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 36nM
Assay Description:
Inhibition of GST-tagged truncated human recombinant LRRK2 G2019S mutant using fluorescein-labeled LRRKtide peptide substrate incubated for 90 mins
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50059307
(CHEMBL3393439 | US9156845, 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 50nM
Assay Description:
Inhibition of LRRK2 in human PBMCs by ActivX KiNativ method
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50059307
(CHEMBL3393439 | US9156845, 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 278nM
Assay Description:
Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELI...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI