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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50201027
(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
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Affinity Data
IC50: 1.01E+3nM
Assay Description:
Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50201027
(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.01E+3nM
Assay Description:
After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4° C. The pellet was resuspended in 5 ml of 5...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Janssen Pharmaceuticals
US Patent
Ligand
BDBM50201027
(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
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Copy InChI
Affinity Data
IC50: 1.01E+3nM
Assay Description:
After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Janssen Pharmaceuticals
US Patent
Ligand
BDBM50201027
(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.47E+3nM
Assay Description:
Binding was terminated by filtration of the incubated membrane preparations using Filtermat B (Pharmacia, Uppsala Sweden) and a Micro Cell Harvester ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Janssen Pharmaceuticals
US Patent
Ligand
BDBM50201027
(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.47E+3nM
Assay Description:
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI