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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201027(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Affinity DataIC50:  1.01E+3nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201027(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Affinity DataIC50:  1.01E+3nMAssay Description:After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4° C. The pellet was resuspended in 5 ml of 5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50201027(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Affinity DataIC50:  1.01E+3nMAssay Description:After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50201027(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Affinity DataIC50:  3.47E+3nMAssay Description:Binding was terminated by filtration of the incubated membrane preparations using Filtermat B (Pharmacia, Uppsala Sweden) and a Micro Cell Harvester ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50201027(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Affinity DataIC50:  3.47E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed