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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18198(1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H...)
Affinity DataKi:  1.60nM ΔG°:  -52.2kJ/mole EC50:  1.40nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18198(1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H...)
Affinity DataKi:  2.00E+3nM ΔG°:  -30.2kJ/molepH: 7.4 T: 2°CAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18198(1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H...)
Affinity DataKi:  8.80E+3nM ΔG°:  -26.8kJ/molepH: 7.4 T: 2°CAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed