Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
St. Jude Research Hospital

LigandBDBM22825(7-(trifluoromethyl)-2,3-dihydro-1H-indole-2,3-dion...)Copy SMILESCopy InChI

Affinity DataKi:  2.15E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Research Hospital

LigandBDBM22825(7-(trifluoromethyl)-2,3-dihydro-1H-indole-2,3-dion...)Copy SMILESCopy InChI

Affinity DataKi:  1.31E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCoagulation factor XII(Homo sapiens (Human))
St. Jude Research Hospital

LigandBDBM22825(7-(trifluoromethyl)-2,3-dihydro-1H-indole-2,3-dion...)Copy SMILESCopy InChI

Affinity DataKi:  3.34E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandBDBM22825(7-(trifluoromethyl)-2,3-dihydro-1H-indole-2,3-dion...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandBDBM22825(7-(trifluoromethyl)-2,3-dihydro-1H-indole-2,3-dion...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI