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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Peking University
Curated by
ChEMBL
Ligand
BDBM50343912
(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
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Affinity Data
IC50: 220nM
Assay Description:
Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Peking University
Curated by
ChEMBL
Ligand
BDBM50343912
(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 730nM
Assay Description:
Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Peking University
Curated by
ChEMBL
Ligand
BDBM50343912
(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
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Copy InChI
Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Peking University
Curated by
ChEMBL
Ligand
BDBM50343912
(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.14E+4nM
Assay Description:
Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
Peking University
Curated by
ChEMBL
Ligand
BDBM50343912
(1-(2-(4-(2-(Trifluoromethyl)phenoxy)phenoxy)ethyl)...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI