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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Androgen receptor
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50319614
(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
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Affinity Data
IC50: 60nM
Assay Description:
Antagonist activity at androgen receptor in human MDA-MB-453 cells coexpressing MMTV-ARE reporter gene assessed as inhibition of DHT-induced response
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Androgen receptor
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50319614
(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 488nM
Assay Description:
Displacement of [3H]DHT from human AR expressed in baculovirus Sf9 cells system by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Progesterone receptor
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50319614
(4-(2,4-Difluorophenoxy)-2-(trifluoromethyl)benzoni...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Binding affinity to progesterone receptor by PRB assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI