Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50376468(CHEMBL259054)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50376468(CHEMBL259054)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50376468(CHEMBL259054)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50376468(CHEMBL259054)
Affinity DataIC50:  299nMAssay Description:Antagonist activity at rat mGluR2 expressed in CHO cells assessed as inhibition of glutamta-induced GIRK currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed