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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Serotonin 2 (5-HT2) receptor
(RAT)
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM50001778
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
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Affinity Data
IC50: 0.0820nM
Assay Description:
Inhibition of [3H]ketanserin binding to rat 5-hydroxytryptamine 2 receptors.
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Target Info
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM50001778
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
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Affinity Data
IC50: 0.720nM
Assay Description:
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor from rat cortical membranes.
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM50001778
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
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Affinity Data
IC50: 3nM
Assay Description:
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of whole rat brain membranes
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Tcg Lifesciences
Curated by
ChEMBL
Ligand
BDBM50001778
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
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Affinity Data
IC50: 6.92nM
Assay Description:
Inhibition of human ERG
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Tcg Lifesciences
Curated by
ChEMBL
Ligand
BDBM50001778
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
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Affinity Data
IC50: 7nM
Assay Description:
Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM50001778
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
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Affinity Data
IC50: 18nM
Assay Description:
Tested for the inhibition of [3H]-spiperone binding to dopamine D2 receptor
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM50001778
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
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Affinity Data
IC50: 18nM
Assay Description:
Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes
More data for this Ligand-Target Pair
Target Info
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Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM50001778
((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
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Copy InChI
Affinity Data
IC50: 18nM
Assay Description:
Binding affinity at dopamine D2 receptor by [3H]-Spiperone displacement.
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI