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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Neuromedin-K receptor
(Homo sapiens (Human))
Euroscreen
Curated by
ChEMBL
Ligand
BDBM50081274
(CHEMBL3422004 | US10544150, Compound 39)
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Affinity Data
Ki: 398nM
Assay Description:
Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Neuromedin-K receptor
(Homo sapiens (Human))
Euroscreen
Curated by
ChEMBL
Ligand
BDBM50081274
(CHEMBL3422004 | US10544150, Compound 39)
Copy SMILES
Copy InChI
Affinity Data
Ki: 750nM
Assay Description:
The ability of the compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist SB222200 was assessed by an in vitro r...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
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Target
Neuromedin-K receptor
(Homo sapiens (Human))
Euroscreen
Curated by
ChEMBL
Ligand
BDBM50081274
(CHEMBL3422004 | US10544150, Compound 39)
Copy SMILES
Copy InChI
Affinity Data
IC50: 398nM
Assay Description:
Antagonist activity at recombinant human NK3R expressed in CHO cells assessed as inhibition of NKB-induced Ca2+ signaling by aequorin Ca2+ biolumines...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Euroscreen
Curated by
ChEMBL
Ligand
BDBM50081274
(CHEMBL3422004 | US10544150, Compound 39)
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Affinity Data
IC50: 2.10E+4nM
Assay Description:
Inhibition of CYP1A2 (unknown origin) by luciferase reporter assay in presence of NADPH regeneration system
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Euroscreen
Curated by
ChEMBL
Ligand
BDBM50081274
(CHEMBL3422004 | US10544150, Compound 39)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP2C19 (unknown origin) by luciferase reporter assay in presence of NADPH regeneration system
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Euroscreen
Curated by
ChEMBL
Ligand
BDBM50081274
(CHEMBL3422004 | US10544150, Compound 39)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP2C9 (unknown origin) by luciferase reporter assay in presence of NADPH regeneration system
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Euroscreen
Curated by
ChEMBL
Ligand
BDBM50081274
(CHEMBL3422004 | US10544150, Compound 39)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP3A4 (unknown origin) by luciferase reporter assay in presence of NADPH regeneration system
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Euroscreen
Curated by
ChEMBL
Ligand
BDBM50081274
(CHEMBL3422004 | US10544150, Compound 39)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of CYP2D6 (unknown origin) by luciferase reporter assay in presence of NADPH regeneration system
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI