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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Cracow University Of Technology
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 0.0600nM
Assay Description:
Displacement of [3H]ketanserin from 5HT2A receptor in rat cortical membranes incubated for 15 mins by liquid scintillation spectrometry
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
Beijing Normal University
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 0.260nM
Assay Description:
Binding affinity to rat cerebral cortex homogenate 5-HT2 receptor assessed as inhibition constant
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
Beijing Normal University
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 0.260nM
Assay Description:
Binding constant against 5-hydroxytryptamine 2 receptor (in vivo)
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 25nM
Assay Description:
Binding constant against histamine H1 receptor (in vivo)
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
Beijing Normal University
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 38nM
Assay Description:
Binding affinity to rat cerebral cortex homogenate alpha 1 adrenergic receptor assessed as inhibition constant
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 38nM
Assay Description:
Binding constant against Alpha-1 adrenergic receptor (in vivo)
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 70nM
Assay Description:
Binding constant against 5-hydroxytryptamine 1A receptor (in vivo)
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 70nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat hippocampal membranes preincubated for 5 mins followed by addition of [3H]-8-OHDPAT and mea...
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 200nM
Assay Description:
Inhibition of human ERG channel
More data for this Ligand-Target Pair
Target Info
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: 200nM
Assay Description:
Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1
More data for this Ligand-Target Pair
Target Info
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding constant against dopamine receptor D2 (in vivo)
More data for this Ligand-Target Pair
Target Info
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Copy InChI
Affinity Data
Ki: >1.00E+3nM
Assay Description:
Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatal membranes incubated for 40 mins
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
Beijing Normal University
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.5nM
Assay Description:
The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
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Affinity Data
IC50: 103nM
Assay Description:
The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)
More data for this Ligand-Target Pair
Target Info
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by
ChEMBL
Ligand
BDBM50010044
(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+3nM
Assay Description:
The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
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In Depth
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