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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50:  158nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50:  3.39E+3nMAssay Description:Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed