Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 15 hits in this display
BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
IC50: 1.10nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
IC50: 5.5nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
BDBM154634(US8999957, Table 1, Compound 2)IC50: 14.4nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
BDBM154634(US8999957, Table 1, Compound 2)
IC50: 28.1nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
BDBM154598(US8999957, Column 153, Compound 3 | US8999957, Tab...)IC50: 166nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
BDBM154598(US8999957, Column 153, Compound 3 | US8999957, Tab...)
IC50: 166nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
BDBM154598(US8999957, Column 153, Compound 3 | US8999957, Tab...)
IC50: 224nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
BDBM154598(US8999957, Column 153, Compound 3 | US8999957, Tab...)
IC50: 224nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
BDBM154598(US8999957, Column 153, Compound 3 | US8999957, Tab...)
Kd: 38nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
BDBM154634(US8999957, Table 1, Compound 2)
Kd: 0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
BDBM154598(US8999957, Column 153, Compound 3 | US8999957, Tab...)
Kd: 38nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
BDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Kd: 0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair