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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)/Neuronal acetylcholine receptor subunit beta-2
(Rattus norvegicus (Rat))
Research Triangle Institute
US Patent
Ligand
BDBM221035
(US9284322, Table 6, Compound 1)
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Affinity Data
Ki: 0.350nM ΔG°: -54.0kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Research Triangle Institute
US Patent
Ligand
BDBM221035
(US9284322, Table 6, Compound 1)
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Affinity Data
Ki: 5.50E+3nM
pH: 7.4
Assay Description:
Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Rattus norvegicus (Rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50448764
(CHEMBL3128036)
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Affinity Data
IC50: 1.80E+4nM
Assay Description:
Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current by two-elect...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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