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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
10
hits in this display
Target
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human))
Saarland University
Curated by
ChEMBL
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
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Affinity Data
IC50: 2.90nM
Assay Description:
Inhibition of human CYP11B2 expressed in hamster V79 MZh cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human))
Saarland University
Curated by
ChEMBL
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3nM
T: 2°C
Assay Description:
V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
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Target
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human))
Saarland University
Curated by
ChEMBL
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3nM
Assay Description:
The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Homo sapiens (Human))
Saarland University
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
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Affinity Data
IC50: 686nM
Assay Description:
The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Homo sapiens (Human))
Saarland University
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
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Affinity Data
IC50: 686nM
pH: 7.4 T: 2°C
Assay Description:
A solution of 6.25 nmol of progesterone (in 5 μl of MeOH) was dissolved in 140 μl of phosphate buffer (0.05 M; pH 7.4; 1 mM MgCl2; 0.1 mM EDTA ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human))
Saarland University
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
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Affinity Data
IC50: 691nM
pH: 7.4 T: 2°C
Assay Description:
The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human))
Saarland University
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 691nM
T: 2°C
Assay Description:
V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human))
Saarland University
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 691nM
Assay Description:
Inhibition of human CYP11B1 expressed in hamster V79 MZh cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aromatase
(Homo sapiens (Human))
Saarland University
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
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Affinity Data
IC50: >3.60E+4nM
Assay Description:
The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aromatase
(Homo sapiens (Human))
Saarland University
Ligand
BDBM8909
(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
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Affinity Data
IC50: >3.60E+4nM
Assay Description:
Inhibition of human placental CYP19
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI