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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 28 hits in this display   

TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataKi:  1.74E+3nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK3a expressed in sS9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataKi:  2.43E+3nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK1(Q)1b expressed in sS9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataKi:  3.23E+3nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK2(VCR)a expressed in sS9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA4o expressed in sS9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA2(R)o expressed in sS9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  6.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1c in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  5.90E+5nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR4a in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  1.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5a in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  1.00E+6nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR6 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  1.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR3 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  4.30E+4nMAssay Description:Activity at rat cloned mGluR1a expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  1.10E+5nMAssay Description:Activity at rat cloned mGluR2 expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned mGluR4 expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR3 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR5 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR1 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR2 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Mus musculus)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50: >1.00E+5nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  3.50E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  1.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5a in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  8.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5b in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  6.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1a in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  6.00E+3nMAssay Description:Effective concentration of the compound for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Cns Research

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Affinity DataEC50:  4.40E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1b in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed