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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Sirtris A Gsk
Curated by
ChEMBL
Ligand
BDBM50431112
(CHEMBL2332047)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human))
Sirtris A Gsk
Curated by
ChEMBL
Ligand
BDBM50431112
(CHEMBL2332047)
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Copy InChI
Affinity Data
IC50: 8.60E+3nM
Assay Description:
Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
Sirtris A Gsk
Curated by
ChEMBL
Ligand
BDBM50431112
(CHEMBL2332047)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.50E+4nM
Assay Description:
Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI