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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50274185
((-)-8-Chloro-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-...)
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Affinity Data
Ki: 3.74nM
Assay Description:
Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membrane
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50274185
((-)-8-Chloro-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.74nM
Assay Description:
Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membrane
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50274185
((-)-8-Chloro-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-...)
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Copy InChI
Affinity Data
Ki: 6.21nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50274185
((-)-8-Chloro-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.21nM
Assay Description:
Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50274185
((-)-8-Chloro-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 56.5nM
Assay Description:
Inhibition of 5-HT transporter-mediated [3H]5HT uptake in human Jar cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50274185
((-)-8-Chloro-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 61.4nM
Assay Description:
Inhibition of 5-HT transporter-mediated [3H]5HT uptake in human Jar cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50274185
((-)-8-Chloro-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 125nM
Assay Description:
Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50274185
((-)-8-Chloro-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+3nM
Assay Description:
Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI