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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetBone morphogenetic protein 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human procollagen C-proteinase assessed as [3H]procollagen turnover by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human procollagen C-proteinase assessed as [3H]procollagen turnover by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human procollagen C-proteinase expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  900nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MMP3 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MMP9 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MMP14 catalytic domain by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of interstitial MMP1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216795((3R)-6-cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-y...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of human MMP2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed