Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 53 hits in this display
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: 50nM ΔG°: -43.3kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: 50nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: >4.00E+4nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: >4.00E+4nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
BDBM50155773(CHEMBL3781751 | US9469597, 5)
Ki: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: >4.00E+4nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: >4.00E+4nMAssay Description:Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
Ki: >4.00E+4nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
IC50: 15nMpH: 7.4 T: 2°CAssay Description:The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: 15nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: 33nMpH: 7.4 T: 2°CAssay Description:The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: 33nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: 292nMpH: 7.4 T: 2°CAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM50155773(CHEMBL3781751 | US9469597, 5)
IC50: 4.84E+4nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastoris preincubated for 15 mins measured after 30 mins by bioluminescent-coupled assayMore data for this Ligand-Target Pair
BDBM50155773(CHEMBL3781751 | US9469597, 5)
IC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMAssay Description:Inhibition of human full length LSD2 using biotin-labeled H3K4me2 (1 to 24 residues) as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM50155773(CHEMBL3781751 | US9469597, 5)
IC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MAOB expressed in Pichia pastoris preincubated for 15 mins measured after 30 mins by bioluminescent-coupled assayMore data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
BDBM50155773(CHEMBL3781751 | US9469597, 5)
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
BDBM50155773(CHEMBL3781751 | US9469597, 5)
IC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
IC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
EC50: 0.950nMAssay Description:Inhibition of LSD1 in human MV-4-11 cells assessed as increase in CD86 mRNA expression after 10 days by SYBR Green dye-bsed RT-qPCR analysisMore data for this Ligand-Target Pair
BDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)
EC50: >20nMAssay Description:Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaMore data for this Ligand-Target Pair
Displayed 1 to 50 (of 53 total ) | Next | Last >>