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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
30
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
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Affinity Data
Ki: 3.90nM
Assay Description:
Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
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Affinity Data
Ki: 5nM
Assay Description:
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Ample...
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
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Affinity Data
Ki: 72nM
Assay Description:
Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
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Affinity Data
Ki: 84nM
Assay Description:
Inhibition constant against human recombinant Monoamine oxidase-B
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Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
Hacettepe University
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
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Affinity Data
Ki: >2.50E+5nM
Assay Description:
Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Ample...
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate addition
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of MAO-B (unknown origin)
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Target
Amine oxidase [flavin-containing] B
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
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Affinity Data
IC50: 22nM
Assay Description:
In vitro inhibitory activity against monoamine oxidase B (MAO-B) in rat brain homogenate.
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Target
Amine oxidase [flavin-containing] B
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 30nM
Assay Description:
In vitro inhibitory activity against rat brain Monoamine oxidase B
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 33nM
Assay Description:
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophoto...
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Target Info
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 37nM
Assay Description:
Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric method
More data for this Ligand-Target Pair
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of recombinant human MAO-B expressed in insect cells assessed as inhibition of oxidation of kynuramine to 4-hydroxyquinoline after 20 mins...
More data for this Ligand-Target Pair
Target Info
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of human recombinant MAO-B expressed in insect cell microsome assessed as 4-hydroxyquinoline formation using kynuramine as substrate after...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of recombinant human MAO-B after 20 mins using 50 uM kynuramine as substrate by fluorescence spectrophotometry
More data for this Ligand-Target Pair
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of human MAO-B expressed in baculovirus infected BT1 cells microsome fraction by fluorescence spectrometry
More data for this Ligand-Target Pair
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of human recombinant MAOB using kynuramine substrate assessed as reduction in MAO-generated 4-hydroxyquinoline level by fluorescence spect...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of human recombinant MAO-B assessed as kynuramine oxidation to 4-hydroxyquinoline formation by spectrofluorometric analysis
More data for this Ligand-Target Pair
Target Info
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Reversible inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 2...
More data for this Ligand-Target Pair
Target Info
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of human recombinant monoamine oxidase-B assessed as kynuramine conversion to 6-hydroxyquinoline after 20 mins by fluorescence spectrophot...
More data for this Ligand-Target Pair
Target Info
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of recombinant human MAOB expressed in insect cell microsomes using kynuramine as substrate measured after 20 mins by fluorescence spectro...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of human recombinant MAO-B expressed in insect cells microsomes assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as...
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by flu...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of recombinant human MAO-B using kynuramine as substrate assessed as 4-hydroxyquinoline production after 30 mins by fluorescence spectroph...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
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Copy BDB DOI
Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of recombinant human MAO-B using kynuramine as substrate after 20 mins by fluorescence spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 91nM
Assay Description:
Inhibition of human recombinant MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 120nM
Assay Description:
Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for 30 mins followed by substrate addition
More data for this Ligand-Target Pair
Target Info
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Target
Amine oxidase [flavin-containing] A
(Rattus norvegicus (rat))
Université
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
In vitro inhibitory activity against rat brain Monoamine oxidase A
More data for this Ligand-Target Pair
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Target
Amine oxidase [flavin-containing] A
(Rattus norvegicus (rat))
Université
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.
More data for this Ligand-Target Pair
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
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Affinity Data
Kd: 66nM
Assay Description:
Binding affinity to human recombinant microsomal MAO-B by ITC
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Dart Neuroscience
Curated by
ChEMBL
Ligand
BDBM50029816
(5-Chloro-pyridine-2-carboxylic acid (2-amino-ethyl...)
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Affinity Data
EC50: 7.10E+3nM
Assay Description:
Inhibition of human recombinant soluble MAO-B assessed as thermal shift after 20 mins by SYPRO orange staining-based fluorescence assay
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