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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
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Target
5-hydroxytryptamine receptor 2B
(RAT)
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
Ki: 5.65nM
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Target
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human))
Eli Lilly
Curated by
PDSP K
i
Database
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
Copy SMILES
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Affinity Data
Ki: 11nM
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Target
Myeloperoxidase
(Homo sapiens (Human))
Universite£? Libre De Bruxelles
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of recombinant MPO mediated taurine chlorination by microplate reader method
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Target
Myeloperoxidase
(Homo sapiens (Human))
Universite£? Libre De Bruxelles
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
IC50: 790nM
Assay Description:
Inhibition of recombinant human myeloperoxidase
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Target Info
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Target
Myeloperoxidase
(Homo sapiens (Human))
Universite£? Libre De Bruxelles
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
IC50: 940nM
Assay Description:
Inhibition of recombinant MPO mediated LDL oxidation using MPO/Cl-/H2O2 system
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Target Info
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Target
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human))
Renovis
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
IC50: 1.23E+4nM
Assay Description:
Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 m...
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Target
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human))
Renovis
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
IC50: 1.31E+4nM
Assay Description:
Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mi...
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
EC50: 2.60nM
Assay Description:
Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assay
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
EC50: 82nM
Assay Description:
Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assay
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Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
EC50: 464nM
Assay Description:
Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assay
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
EC50: 10nM
Assay Description:
Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assay
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Target
Sphingosine 1-phosphate receptor 3
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
EC50: >4.00E+4nM
Assay Description:
External Assay ID: S1P3_EC50_CS_5HT1e_Agonist Name: S1P3 Dose Response Assay Counterscreen for 5-Hydroxytryptamine(Serotonin) Receptor Subtype 1E ...
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
EC50: 1.86E+4nM
pH: 7.4 T: 2°C
Assay Description:
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 2.22E+3nM
pH: 7.4 T: 2°C
Assay Description:
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 1E
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM30853
(2-(5-fluoranyl-1H-indol-3-yl)ethanamine;hydrochlor...)
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Affinity Data
EC50: 484nM
pH: 7.4 T: 2°C
Assay Description:
The CHO cell line was cultured in T-175 sq cm Corning flasks (part 431080) at 37 deg C and 95% RH. The HTS assay began by dispensing 10 microliters o...
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Target Info
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