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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50052702(2-(4-Aminophenyl)benzothiazole | 4-Benzothiazol-2-...)
Affinity DataKi:  37nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
"A. Moro" University Of Bari

Curated by ChEMBL
LigandPNGBDBM50052702(2-(4-Aminophenyl)benzothiazole | 4-Benzothiazol-2-...)
Affinity DataIC50:  7.90E+4nMAssay Description:Inhibition of recombinant human MMP9 catalytic domain (Phe107 to Pro449 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
"A. Moro" University Of Bari

Curated by ChEMBL
LigandPNGBDBM50052702(2-(4-Aminophenyl)benzothiazole | 4-Benzothiazol-2-...)
Affinity DataIC50:  8.80E+4nMAssay Description:Inhibition of recombinant human MMP8 catalytic domain (Phe99 to Gln269 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-Al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
"A. Moro" University Of Bari

Curated by ChEMBL
LigandPNGBDBM50052702(2-(4-Aminophenyl)benzothiazole | 4-Benzothiazol-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human MMP2 catalytic domain (Tyr110 to Asp452 residues) expressed in yeast cells using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2/...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
"A. Moro" University Of Bari

Curated by ChEMBL
LigandPNGBDBM50052702(2-(4-Aminophenyl)benzothiazole | 4-Benzothiazol-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human MMP13 catalytic domain (Tyr104 to Asn274 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed