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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
22
hits in this display
Target
Protein cereblon
(Homo sapiens (Human))
Usona Institute
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
Ki: 1.49E+3nM
Assay Description:
Binding affinity to CBRN (unknown origin) incubated for 60 mins by lenalidomide displacement assay
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Target
Protein cereblon
(Homo sapiens (Human))
Usona Institute
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
Ki: 1.49E+3nM
Assay Description:
TBD
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Target
Cereblon isoform 4
(Magnetospirillum gryphiswaldense)
Max Planck Institute For Developmental Biology
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
Ki: 3.10E+3nM
Assay Description:
Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assay
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Target
Protein cereblon
(Homo sapiens (Human))
Usona Institute
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
Ki: 1.63E+4nM
Assay Description:
Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...
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Target
Mediator of DNA damage checkpoint protein 1
(Homo sapiens (Human))
Celgene
US Patent
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: 190nM
T: 2°C
Assay Description:
The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p...
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Target
Tumor necrosis factor
(Homo sapiens (Human))
Celgene
US Patent
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: 220nM
T: 2°C
Assay Description:
The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p...
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KEGG
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Target
Interleukin-1 beta
(Homo sapiens (Human))
Celgene
US Patent
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: 390nM
T: 2°C
Assay Description:
The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p...
More data for this Ligand-Target Pair
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Target
Interleukin-6
(Homo sapiens (Human))
Celgene
US Patent
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: 1.20E+3nM
T: 2°C
Assay Description:
The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p...
More data for this Ligand-Target Pair
Target Info
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Target
DNA damage-binding protein 1/Protein cereblon
(Homo sapiens (Human))
Celgene
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: 1.50E+3nM
pH: 7.0
Assay Description:
The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that...
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Target
Protein cereblon
(Homo sapiens (Human))
Usona Institute
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
To measure compound binding to endogenous CRBN.
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Target
DNA damage-binding protein 1/Protein cereblon
(Homo sapiens (Human))
Celgene
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: 3.00E+3nM
pH: 8.0 T: 2°C
Assay Description:
Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Usona Institute
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: 5.19E+3nM
Assay Description:
Inhibition of BRD4 bromodomain 2 (unknown origin) in HEK293 cells cotransfected with eGFP by flow cytometry based mCherry reporter gene analysis
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Target
Protein cereblon
(Homo sapiens (Human))
Usona Institute
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
Copy SMILES
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Affinity Data
IC50: 5.19E+3nM
Assay Description:
TBD
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Target
C-C motif chemokine 3
(Homo sapiens (Human))
Celgene
US Patent
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: >1.00E+4nM
T: 2°C
Assay Description:
The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p...
More data for this Ligand-Target Pair
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Target
Granulocyte-macrophage colony-stimulating factor
(Homo sapiens (Human))
Celgene
US Patent
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: >1.00E+4nM
T: 2°C
Assay Description:
The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p...
More data for this Ligand-Target Pair
Target Info
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Target
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
(Leishmania mexicana)
Celgene
US Patent
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: >1.00E+4nM
T: 2°C
Assay Description:
The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p...
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
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US Patent
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Target
C-C motif chemokine 4
(Homo sapiens (Human))
Celgene
US Patent
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
T: 2°C
Assay Description:
The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
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DrugBank
MCE
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Target
Protein cereblon
(Homo sapiens (Human))
Usona Institute
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.78E+4nM
Assay Description:
Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
GoogleScholar
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DrugBank
MCE
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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KEGG
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM65454
(191732-72-6 | CC-5013 | Lenalidomide | Revimid | R...)
Copy SMILES
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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DrugBank
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PubMed
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