Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 268 hits in this display
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 34nMAssay Description:Inhibition of recombinant human HDAC6 using ZMAL (Z-(Ac)Lys-AMC as substrate incubated for 20 mins and measured by homogenous fluorescence assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 99nMAssay Description:Inhibition of recombinant human full length HDAC1 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 140nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) using of Fluor-de-Lys substrate incubated for 10 mins by fluorimetric assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 210nMAssay Description:HDACs assay was performed according to standard Protocols (Fluorgenic HDACs 1, 2, and 3 assay kit, BPS Bioscience™). All of the compounds, with Chida...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 248nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 250nMAssay Description:HDACs assay was performed according to standard Protocols (Fluorgenic HDACs 1, 2, and 3 assay kit, BPS Bioscience™). All of the compounds, with Chida...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 250nMAssay Description:HDACs assay was performed according to standard Protocols (Fluorgenic HDACs 1, 2, and 3 assay kit, BPS Bioscience™). All of the compounds, with Chida...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 250nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 400nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 400nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 453nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 524nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extracts using color de Lys as substrate measured after 30 mins by colorimetric assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 540nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 720nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 720nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 740nMAssay Description:Inhibition of recombinant human full length HDAC2 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 790nMAssay Description:Inhibition of KDAC3 in human K562 cells using [3H]acetylated histone as substrate incubated for 10 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 930nMAssay Description:Inhibition of recombinant human HDAC1 using ZMAL (Z-(Ac)Lys-AMC as substrate incubated for 20 mins and measured by homogenous fluorescence assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 980nMAssay Description:HDACs assay was performed according to standard Protocols (Fluorgenic HDACs 1, 2, and 3 assay kit, BPS Bioscience™). All of the compounds, with Chida...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 980nMAssay Description:HDACs assay was performed according to standard Protocols (Fluorgenic HDACs 1, 2, and 3 assay kit, BPS Bioscience™). All of the compounds, with Chida...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 1.48E+3nMAssay Description:Inhibition of KDAC1 in human K562 cells using [3H]acetylated histone as substrate incubated for 10 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 1.80E+3nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract incubated for 30 mins by fluorescence-based Glo-luminescence assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 3.20E+3nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 3.20E+3nMAssay Description:HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are describe...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 6.00E+3nMAssay Description:Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 6.73E+3nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using fluor de lys as substrate after 10 to 15 mins by spectrofluorometryMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: 8.02E+3nMAssay Description:Inhibition of HDAC in human HeLa cells using fluor de Lys as substrate incubated for 20 mins by microplate spectrofluorometric analysisMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length HDAC4 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length HDAC6 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length HDAC8 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 1 (unknown origin) using [Lys (5,8,12,16) Ac] H4(1-21) as substrate by fluorescence based assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMAssay Description:Inhibition of His-tagged BRD4 bromodomain 2 (unknown origin) using [Lys (5,8,12,16) Ac] H4(1-21) as substrate by fluorescence based assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >3.00E+4nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >3.00E+4nMAssay Description:Inhibition of KDAC6 in human K562 cells using [3H]acetylated histone as substrate incubated for 10 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
IC50: >3.00E+4nMAssay Description:Inhibition of KDAC8 in human K562 cells using [3H]acetylated histone as substrate incubated for 10 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
pH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Kd: 156nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
BDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
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