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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
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Target
Adenosine receptor A1
(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by
ChEMBL
Ligand
BDBM50008368
((2R,3S)-5-(6-Amino-2-chloro-purin-9-yl)-4-fluoro-2...)
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Affinity Data
Ki: 640nM
Assay Description:
Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.
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Target
Adenosine receptor A2a
(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by
ChEMBL
Ligand
BDBM50008368
((2R,3S)-5-(6-Amino-2-chloro-purin-9-yl)-4-fluoro-2...)
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Affinity Data
Ki: 897nM
Assay Description:
Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand
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Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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Target
Adenosine receptor A3
(Rattus norvegicus)
National Institute Of Diabetes
Curated by
ChEMBL
Ligand
BDBM50008368
((2R,3S)-5-(6-Amino-2-chloro-purin-9-yl)-4-fluoro-2...)
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Affinity Data
Ki: 8.24E+4nM
Assay Description:
Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably trans...
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Target
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human))
East China University Of Science And Technology
Curated by
ChEMBL
Ligand
BDBM50247921
(CHEBI:681569 | Clofarabine | Clolar | Evoltra)
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Affinity Data
IC50: 3.12E+3nM
Assay Description:
Inhibition of recombinant human PDE2A catalytic domain (580 to 919 residues) expressed in Escherichia coli BL21 (Codonplus) using [3H]cGMP as substra...
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MCE
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50247921
(CHEBI:681569 | Clofarabine | Clolar | Evoltra)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target Info
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MCE
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50247921
(CHEBI:681569 | Clofarabine | Clolar | Evoltra)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target Info
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50247921
(CHEBI:681569 | Clofarabine | Clolar | Evoltra)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50247921
(CHEBI:681569 | Clofarabine | Clolar | Evoltra)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
PC cid
PC sid
In Depth
Details
Article
PubMed
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